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Batch Documentation-Identity & Purity Control

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Read more about MK-677 Ibutamoren in our research article →

Research Compound Summary

MK-677, also known as Ibutamoren or MK-0677, is a non peptide small molecule researched as an agonist of the ghrelin receptor GHSR1a, often used as a laboratory probe for growth hormone secretagogue signalling. In controlled model systems it is applied to study receptor binding, activation kinetics, and downstream second messenger pathways, including calcium flux, MAPK phosphorylation patterns, and transcriptional reporter outputs linked to GHSR1a engagement. Researchers also use MK-677 to support assay development and validation, for example comparing agonist potency across cell lines, evaluating desensitisation and internalisation behaviour, and running counter screens for off target activity. In preclinical settings it may be used to explore endocrine axis dynamics by tracking circulating biomarker changes in animal models, alongside tissue level gene expression panels and proteomic readouts. These studies treat MK-677 as a reference compound for interpreting ghrelin pathway modulation under defined experimental conditions.

Technical Specification

Synonyms: Ibutamoren, MK-0677, L-163,191
Chemical class: Non peptide ghrelin receptor agonist
Long chemical name: (IUPAC style listing): Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4′-piperidin]-1′-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-
Molecular weight: 624.8 g/mol
Formula: C27H36N4O5S
Contains: 9.99% Ibutamoren (MK-677)
CAS/Batch: 001-03-2026
Storage: Store between 10-15°C
Purity: 99.7%- (documented under batch specific testing)

Related Research Compounds

MK-688-Ostarine
RAD-140-Testolone
LGD-4033-Ligandrol

Disclaimer

For research purpose only, Not for human consumption